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The best way to clean your can opener blade is to use an old toothbrush loaded with anti-bacterial dish soap and scrub vigorously. Your can opener blade should be cleaned frequently to prevent bacteria.
It is not recommended by the CDC (Center for Disease Control) to use anti-bacterial soap unless directed to by a doctor. Using this type of soap causes and increase in antibiotic resistant microorganisms, something you don't want in your kitchen or your body.